Brain-derived neurotrophic factor, nerve growth factor, and high sensitivity C-reactive protein levels in urine in overactive bladder patients: a meta-analysis

Background: Overactive bladder (OAB) is a clinical syndrome characterized by combination of symptoms including urgency, frequency, and nocturia, with or without urinary incontinence. has high prevalence especially in those an older age women, diagnosis depending on the patient’s symptoms. This study aims to assess brain-derived neurotrophic factor (BDNF), nerve growth (NGF), sensitivity C-reactive protein (HSCRP) urine as biomarkers OAB. Methods: Studies were searched from Pubmed, Science Direct, Wiley Online Library, Google Scholar. All studies assessing BDNF, NGF, HSCRP OAB patients included. The standardized mean difference (SMD) 95% confidence intervals (CI) then calculated. Results: A total 85 included 11,483 subjects (6,885 4,598 controls). Based data analysis results, NGF/Creatinine (NGF/Cr) NGF level significantly higher than control (SMD = 1.00, 95%CI 0.80-1.20, P<0.00001; SMD 1.11, 0.79-1.43, P<0.00001). NGF/Cr was found incontinence (OAB wet) compared dry) 0.41, 0.23-0.60, P<0.0001), decreased after treatment 0.76, 0.49-1.03, Urinary BDNF/Cr controls 1.97, 1.14-2.79, P<0.00001), also 0.75, 0.42-1.08, when 0.38, 0.12-0.64, P<0.004). Conclusions: BDNF/Cr, NGF/Cr, controls, which means they may be used for OAB.